Substance over noise

Latest Essay

23.3% Weight Loss in Type 2 Diabetes. Can Patients Stay on Treatment?

Oct 6, 2026 · GLP-1 Pipeline · Substance Over Noise

Read Essay →

Mechanism

Glucagon Was the Villain. Amylin Was a Footnote.

Oct 3, 2026 · Obesity Science

Retatrutide

Everyone Will Quote 28%. Read Page Four.

Sep 30, 2026 · GLP-1 Pipeline

Drug Safety

“Did You See the News About Ozempic?”

Sep 26, 2026 · GLP-1

Evidence Review

Twenty-Five Trials on Binge Eating. Three Studied It.

Sep 23, 2026 · Obesity Science

First Person

I’m an Obesity Doctor. I Gained Weight on Tirzepatide.

Sep 19, 2026 · Special Edition

Statins

The Pain Is Real. The Statin Isn’t.

Sep 15, 2026 · Cardiovascular Risk

Imaging

Low Calculated Risk. Plaque Already Present.

Sep 12, 2026 · Cardiovascular Risk

Lipedema

The Fat That Hurts Has a Name.

Sep 9, 2026 · Obesity Medicine

Free Resource

Two Free Tools to Make Sense of Obesity Medications

Sep 8, 2026 · GLP-1 Evidence

Lp(a)

The Drug Worked. The Trial Failed.

Sep 5, 2026 · Cardiovascular Risk

Drug Safety

Sixteen Years of Rat Data. The Human Case Never Arrived.

Sep 1, 2026 · GLP-1

Coverage

Lilly Says Zepbound Pays For Itself. That Is the Weaker Argument.

Aug 29, 2026 · Health Systems

Type 2 Diabetes

Half the Pancreas Is Already Gone. Then We Start Slow.

Aug 25, 2026 · Prevention

Obesity Medicine

The Pendulum Swung Away From Blame. It Swung Too Far.

Aug 22, 2026 · Obesity Medicine

Lipids

It’s Already on Every Panel. Nobody Reads It.

Aug 18, 2026 · Cardiovascular Risk

Lp(a)

One in Five Carry It. Nothing You Prescribe Touches It.

Aug 15, 2026 · Cardiovascular Risk

Health Policy

You Have Insurance. That Isn’t Healthcare.

Aug 11, 2026 · Health Systems

Coverage

Every First Claim Is Denied. That’s the Design.

Aug 8, 2026 · Health Systems

Retatrutide

Retatrutide Won Twice. The Heart Data Didn’t.

Aug 4, 2026 · GLP-1 Pipeline

Inflammation

They Silenced IL-6. Nothing Happened.

Aug 1, 2026 · Cardiovascular Risk

Retatrutide

The Triple Agonist, in Plain Numbers

Jul 28, 2026 · GLP-1 Pipeline

Free Resource

I Put Twelve GLP-1 Trials on One Page

Jul 21, 2026 · GLP-1 Evidence

Lipids

The PCSK9 Pill Is Here. The Needle Was the Barrier.

Jul 18, 2026 · Cardiovascular Risk

Most Read

The Patient Barely Lost Weight. He Got Better Anyway.

Jun 27, 2026 · GLP-1 · Longevity

Coverage

Medicare Will Pay for Wegovy Now. Here’s the Catch.

Jun 23, 2026 · Health Systems

Imaging

Zero Calcium. Doubled Plaque.

Jun 13, 2026 · Cardiovascular Risk

Lp(a)

The Cholesterol You Were Born With

Jun 9, 2026 · Cardiovascular Risk

Clinical Practice

The Side Effect Toolbox: How to Keep Patients On the Drug

Jun 2, 2026 · GLP-1

Most Read

Your Cells Remember the Obesity. The Memory Lasts Years.

May 30, 2026 · Obesity Science

History of Science

The Accidental Hormone

May 23, 2026 · GLP-1

First Person

I’ve Been Taking Low-Dose Tirzepatide for Two Years. Here’s What I’ve Learned.

Mar 9, 2026 · Special Edition